Head to head

OsteoGen Plug vs RegenerOss Bone Graft Plug

Two synthetic mineral-collagen plugs that differ in chemistry, not just branding. OsteoGen (Impladent) is a non-ceramic calcium apatite its manufacturer states is not carbonate apatite; RegenerOss (ZimVie, manufactured by Collagen Matrix) is a carbonate apatite. OsteoGen is radiolucent at placement and turns radiopaque as it mineralizes; RegenerOss publishes a 9 to 12 month resorption window and a typical 6-month implant timing. No clinical trial compares them, and this page does not pick a winner.

Different mineral chemistries
Both bovine collagen carriers
No head-to-head trial exists
Verified 2026-08-21

The difference

Side by side

Two synthetic plugs whose differences are documented facts, and whose similarities include everything the evidence can actually measure.

Attribute	OsteoGen Plug	RegenerOss
Mineral	Non-ceramic bioactive calcium apatite; the manufacturer states it is not β-TCP, not ceramic hydroxyapatite, and not carbonate apatite	80% carbonate apatite granules
Collagen carrier	Type I bovine Achilles tendon; percentage not published	20% Type I bovine collagen
Manufacturer	Impladent Ltd., Jamaica, NY	Collagen Matrix, Inc., per the FDA UDI registration; ZimVie is the brand owner
Sizes	6 × 25 mm, 10 × 20 mm, 15 × 20 mm	6 × 25 mm, 10 × 20 mm
Per box	5 or 10, by size and distributor	5
Radiographic appearance at placement	Radiolucent, becoming radiopaque as it mineralizes, per the manufacturer	Not published; carbonate apatite as a class is radiopaque
Resorption, as published	The manufacturer publishes two figures across its own channels: 3 to 6 months and 4 to 6 months	Full resorption 9 to 12 months
Implant timing, as published	Once fully radiopaque, per the manufacturer	Typically 6 months post-grafting
Membrane, as published	The manufacturer states no membrane is needed and describes compacting the plug to form one	No membrane statement in either direction
Public US price	Not consistently published	Not published

Every row is what each manufacturer or its distributors publish, sourced in the ledger below. "Not published" is a real answer: it tells you what the manufacturer chose not to state.

Reading the table

What the differences do and do not mean

The chemistry difference is real, and its clinical meaning is not established

These minerals are genuinely different materials: Impladent goes out of its way to say what OsteoGen is not, and carbonate apatite is exactly what RegenerOss is. What no published trial establishes is that either chemistry produces better hard-tissue outcomes in a socket. Reviews of ridge preservation have not crowned any material class, and no study compares these two products directly. A confident winner here would be marketing, not evidence.

The radiographic behavior differs on day one

An OsteoGen Plug placed today does not show on today’s radiograph, by design; the manufacturer treats increasing radiopacity as the sign of mineralization. A carbonate apatite plug is visible from placement. Neither behavior is an advantage in itself, but a clinician reading a post-operative film needs to know which one to expect.

The published timelines are not comparable numbers

OsteoGen’s resorption figures (3 to 6 or 4 to 6 months, depending on which of the manufacturer’s channels you read) and RegenerOss’s 9 to 12 months describe different chemistries measured by different companies against no shared standard. Treating them as a race would misread both. Either way, implant readiness is confirmed clinically and radiographically at the site, not from packaging.

Clinical evidence

What the evidence supports, at three different levels

Evidence for the procedure is not evidence for a material class, and neither is evidence for a specific product. These are kept apart on purpose.

Evidence about the procedure

Both sit inside a well-supported procedure

Ridge preservation against unassisted healing shows roughly 1.3–1.5 mm less width loss and 0.9–1.1 mm less height loss, with implants placed as planned at 90.1% of grafted against 79.2% of ungrafted sites. That supports grafting the socket; it does not distinguish these two products.

Willenbacher M, et al. The effects of alveolar ridge preservation: a meta-analysis. Clin Implant Dent Relat Res. 2016;18(6):1248–68.

Evidence about the material classes

No synthetic class is established as superior to another

Reviews have not established any material class as clinically superior for hard-tissue outcomes, and that includes distinctions between calcium phosphate chemistries. Residual graft material at around five months is reported for synthetic blends in human histology; complete early replacement is not the documented norm for any of them.

Evidence about these specific products

No trial compares them, and product-level evidence is thin for both

We found no published study comparing the OsteoGen Plug and the RegenerOss Bone Graft Plug. One registered trial involves OsteoGen against an allograft-plus-membrane arm; its results are not published where we could read them. For RegenerOss we found no independent product-level trials at all. This is the normal state of the category, and it is why this page compares published facts rather than outcomes.

ClinicalTrials.gov. OsteoGen Plug vs. Freeze-dried Bone Allograft With Collagen Barrier. NCT06447844.

Evidence for the procedure and the material classes is not evidence for either product, and no evidence compares the two. The three tiers are kept apart for that reason.

Sources

Ultradent Products, Inc. distributor of Impladent OsteoGen https://www.ultradent.com/products/categories/surgical/bone-grafting/osteogen-bone-grafts
Impladent Ltd. manufacturer brochure, 2021 https://www.kyda.org/res/uploads/media/Impladent-1-OsteoGen-Plug-Brochure-2021.pdf
ZimVie Dental brand owner https://www.zimvie.com/en/dental/biomaterial-solutions/bone-graft-materials/regeneross-bone-graft-plug.html
FDA openFDA UDI database regulatory device registrations; company of record and model numbers for RegenerOss (RGP1020, RGP0625), REGENAFILL (RFP10X20, RFP6X25), PreservaRidge (PRPREG, PRPSLM), OsteoGen Plugs (Impladent), CollaPlug (Integra, model 0102) https://api.fda.gov/device/udi.json
GoldenDent distributor listing https://www.physicsforceps.com/osteogen-plugs-graft

Last verified 2026-08-21. Manufacturers change formulations, packaging and published claims without notice. Every value on this page was read from the source listed against it on that date, and confirming current specifications against the instructions for use in the box remains the clinician's call.

Professional use. This page is product information for licensed dental professionals, compiled from both manufacturers’ published material and FDA device registration records. It is not clinical advice. Implanex sells neither product. Product names and trademarks are the property of their respective owners.

OsteoGen vs RegenerOss questions

Which is better, the OsteoGen Plug or RegenerOss?

No published evidence answers that. No trial compares them, and reviews of ridge preservation have not established any material class as clinically superior for hard-tissue outcomes. The documented differences are chemistry, radiographic appearance at placement, sizes, and what each manufacturer publishes about timing.

Are OsteoGen and RegenerOss the same kind of mineral?

No. Both are synthetic, and Impladent states OsteoGen is a non-ceramic calcium apatite that is not carbonate apatite, while RegenerOss is published as 80% carbonate apatite granules. They are different calcium phosphate chemistries.

Do both plugs contain animal-derived material?

Yes. Both carriers are Type I bovine collagen, OsteoGen’s from Achilles tendon. A synthetic mineral phase does not make the product free of animal-derived material, and that is true across this category.

Why does OsteoGen not show on the post-operative radiograph?

By design: the manufacturer describes the crystals as radiolucent at placement, becoming radiopaque as the site mineralizes, and treats full radiopacity as the sign that host bone has formed. A carbonate apatite plug like RegenerOss is visible from placement instead.